Ontology highlight
ABSTRACT:
SUBMITTER: Sato T
PROVIDER: S-EPMC5411681 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Sato Takahiro T Issa Jean-Pierre J JJ Kropf Patricia P
Cold Spring Harbor perspectives in medicine 20170501 5
Aberrant DNA methylation is a critically important modification in cancer cells, which, through promoter and enhancer DNA methylation changes, use this mechanism to activate oncogenes and silence of tumor-suppressor genes. Targeting DNA methylation in cancer using DNA hypomethylating drugs reprograms tumor cells to a more normal-like state by affecting multiple pathways, and also sensitizes these cells to chemotherapy and immunotherapy. The first generation hypomethylating drugs azacitidine and ...[more]