Regulation of TGF-?-mediated endothelial-mesenchymal transition by microRNA-27.
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ABSTRACT:
SUBMITTER: Suzuki HI
PROVIDER: S-EPMC5412016 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Regulation of TGF-β-mediated endothelial-mesenchymal transition by microRNA-27.
Suzuki Hiroshi I HI Katsura Akihiro A Mihira Hajime H Horie Masafumi M Saito Akira A Miyazono Kohei K
Journal of biochemistry 20170501 5
Multiple microRNAs (miRNAs) regulate epithelial-mesenchymal transition and endothelial-mesenchymal transition (EndMT). Here we report that microRNA-27b (miR-27b) positively regulates transforming growth factor-β (TGF-β)-induced EndMT of MS-1 mouse pancreatic microvascular endothelial cells. TGF-β induced miR-23b/24-1/27b expression, and inhibition of miR-27 suppressed TGF-β-mediated induction of mesenchymal genes. Genome-wide miRNA target analysis revealed that miR-27 targets Elk1, which acts as ...[more]
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