Ontology highlight
ABSTRACT:
SUBMITTER: Ahmad T
PROVIDER: S-EPMC5412025 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Ahmad Taha T Sabet Samie S Primerano Donald A DA Richards-Waugh Lauren L LL Rankin Gary O GO
Journal of analytical toxicology 20170501 4
Cytochrome P450 (CYP) enzyme 2B6 plays a significant role in the stereo-selective metabolism of (S)-methadone to 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine, an inactive methadone metabolite. Elevated (S)-methadone can cause cardiotoxicity by prolonging the QT interval of the heart's electrical cycle. Large inter-individual variability of methadone pharmacokinetics causes discordance in the relationship between dose, plasma concentrations and side effects. The purpose of this study was to deter ...[more]