Ontology highlight
ABSTRACT:
SUBMITTER: Rotoli D
PROVIDER: S-EPMC5412470 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Rotoli Deborah D Morales Manuel M Ávila Julio J Maeso María Del Carmen MDC García María Del Pino MDP Mobasheri Ali A Martín-Vasallo Pablo P
International journal of molecular sciences 20170422 4
Scaffold proteins play pivotal roles in the regulation of signaling pathways, integrating external and internal stimuli to various cellular outputs. We report the pattern of cellular and subcellular expression of scaffoldins angiomotin-like 2 (AmotL2), FK506 binding protein 5 (FKBP51) and IQ motif containing GTPase-activating protein 1 (IQGAP1) in colorectal cancer (CRC) and metastases in liver resected after oxaliplatin-based chemotherapy (CT). Positive immunostaining for the three scaffoldins ...[more]