Centrosome and spindle assembly checkpoint loss leads to neural apoptosis and reduced brain size.

ABSTRACT: Accurate mitotic spindle assembly is critical for mitotic fidelity and organismal development. Multiple processes coordinate spindle assembly and chromosome segregation. Two key components are centrosomes and the spindle assembly checkpoint (SAC), and mutations affecting either can cause human microcephaly. In vivo studies in Drosophila melanogaster found that loss of either component alone is well tolerated in the developing brain, in contrast to epithelial tissues of the imaginal discs. In this study, we reveal that one reason for that tolerance is the compensatory relationship between centrosomes and the SAC. In the absence of both centrosomes and the SAC, brain cells, including neural stem cells, experience massive errors in mitosis, leading to increased cell death, which reduce

SUBMITTER: Poulton JS 

PROVIDER: S-EPMC5412557 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature