Ontology highlight
ABSTRACT:
SUBMITTER: Foldi I
PROVIDER: S-EPMC5412559 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Foldi Istvan I Anthoney Niki N Harrison Neale N Gangloff Monique M Verstak Brett B Nallasivan Mohanakarthik Ponnadai MP AlAhmed Samaher S Zhu Bangfu B Phizacklea Mark M Losada-Perez Maria M Moreira Marta M Gay Nicholas J NJ Hidalgo Alicia A
The Journal of cell biology 20170403 5
Cell number plasticity is coupled to circuitry in the nervous system, adjusting cell mass to functional requirements. In mammals, this is achieved by neurotrophin (NT) ligands, which promote cell survival via their Trk and p75<sup>NTR</sup> receptors and cell death via p75<sup>NTR</sup> and Sortilin. <i>Drosophila</i> NTs (DNTs) bind Toll receptors instead to promote neuronal survival, but whether they can also regulate cell death is unknown. In this study, we show that DNTs and Tolls can switch ...[more]