Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC5412561 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Liu Xuezhao X Li Yang Y Li Yang Y Wang Xin X Xing Ruxiao R Liu Kai K Gan Qiwen Q Gan Qiwen Q Tang Changyong C Gao Zhiyang Z Jian Youli Y Luo Shouqing S Guo Weixiang W Yang Chonglin C
The Journal of cell biology 20170412 5
Autophagy-dependent clearance of ubiquitinated and aggregated proteins is critical to protein quality control, but the underlying mechanisms are not well understood. Here, we report the essential role of the BEACH (beige and Chediak-Higashi) and WD40 repeat-containing protein WDR81 in eliminating ubiquitinated proteins through autophagy. WDR81 associates with ubiquitin (Ub)-positive protein foci, and its loss causes accumulation of Ub proteins and the autophagy cargo receptor p62. WDR81 interact ...[more]