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A mild catalytic system for radical conjugate addition of nitrogen heterocycles.

ABSTRACT: The direct addition of pyridine and diazine units to electron-poor alkenes has been achieved via a redox radical mechanism that is enabled by limiting the effective concentration of the hydrogen-atom source. The described method is tolerant of acidic functional groups and is generally applicable to the union of a wide range of Michael acceptors and 6-membered heterocyclic halides.

SUBMITTER: Aycock RA

PROVIDER: S-EPMC5412691 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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A mild catalytic system for radical conjugate addition of nitrogen heterocycles.

Aycock R A RA Wang H H Jui N T NT

Chemical science 20170213 4

The direct addition of pyridine and diazine units to electron-poor alkenes has been achieved <i>via</i> a redox radical mechanism that is enabled by limiting the effective concentration of the hydrogen-atom source. The described method is tolerant of acidic functional groups and is generally applicable to the union of a wide range of Michael acceptors and 6-membered heterocyclic halides. ...[more]

PMID: 28507687

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