Ontology highlight
ABSTRACT:
SUBMITTER: Horvath BM
PROVIDER: S-EPMC5412863 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Horvath Beatrix M BM Kourova Hana H Nagy Szilvia S Nemeth Edit E Magyar Zoltan Z Papdi Csaba C Ahmad Zaki Z Sanchez-Perez Gabino F GF Perilli Serena S Blilou Ikram I Pettkó-Szandtner Aladár A Darula Zsuzsanna Z Meszaros Tamas T Binarova Pavla P Bogre Laszlo L Scheres Ben B
The EMBO journal 20170320 9
The rapidly proliferating cells in plant meristems must be protected from genome damage. Here, we show that the regulatory role of the <i>Arabidopsis</i> RETINOBLASTOMA RELATED (RBR) in cell proliferation can be separated from a novel function in safeguarding genome integrity. Upon DNA damage, RBR and its binding partner E2FA are recruited to heterochromatic γH2AX-labelled DNA damage foci in an ATM- and ATR-dependent manner. These γH2AX-labelled DNA lesions are more dispersedly occupied by the c ...[more]