HER2-positive breast cancer cells expressing elevated FAM83A are sensitive to FAM83A loss.
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ABSTRACT:
SUBMITTER: Bartel CA
PROVIDER: S-EPMC5413028 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
HER2-positive breast cancer cells expressing elevated FAM83A are sensitive to FAM83A loss.
Bartel Courtney A CA Jackson Mark W MW
PloS one 20170502 5
HER2-positive breast cancer (HER2+ BC) is an aggressive subtype with a poor prognosis. Although the antibody trastuzumab, which targets the HER2 growth factor receptor, has improved survival rates, patients often present with de novo resistance or acquire resistance after an initial response. Identifying new ways to target HER2 signaling will be critical for overcoming trastuzumab resistance. FAM83A is a novel oncogene identified by its ability to confer resistance to EGFR therapies, a receptor ...[more]
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