Low-Dose Aspirin and Sporadic Anovulation in the EAGeR Randomized Trial.

ABSTRACT:

Context

Among women with a single, recent pregnancy loss, daily preconception low-dose aspirin (LDA) increased the live birth rate with no effect on pregnancy loss. Ovulation is a potential mechanism underlying this effect.

Objective

We estimated the effect of LDA on the per-cycle risk of anovulation among eumenorrheic women.

Design

Multicenter, randomized, double-blind, placebo-controlled trial of daily LDA on reproductive outcomes. Preconception follow-up lasted 1 to 6 menstrual cycles (ClinicalTrials.gov, NCT00467363).

Setting

Four US medical centers during 2007 to 2011.

Patients or other participants

Healthy women (n = 1214), age 18 to 40, were attempting pregnancy, had regular menstrual cycles (21 to 42 days), and had a history of 1 to 2 documented

SUBMITTER: Radin RG 

PROVIDER: S-EPMC5413097 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature