Molecular Pathways: Targeting Protein Tyrosine Phosphatases in Cancer.

ABSTRACT: The aberrant activation of oncogenic signaling pathways is a universal phenomenon in cancer and drives tumorigenesis and malignant transformation. This abnormal activation of signaling pathways in cancer is due to the altered expression of protein kinases and phosphatases. In response to extracellular signals, protein kinases activate downstream signaling pathways through a series of protein phosphorylation events, ultimately producing a signal response. Protein tyrosine phosphatases (PTP) are a family of enzymes that hydrolytically remove phosphate groups from proteins. Initially, PTPs were shown to act as tumor suppressor genes by terminating signal responses through the dephosphorylation of oncogenic kinases. More recently, it has become clear that several PTPs overexpressed in human ca

SUBMITTER: Bollu LR 

PROVIDER: S-EPMC5413367 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature