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Methodological Quality of Studies of Endstage Renal Disease in Lupus Nephritis, 1970 to 2015.


ABSTRACT: OBJECTIVE:To examine trends in methodological quality of studies of endstage renal disease risk in lupus nephritis, 1970-2015. METHODS:We assessed quality using the Newcastle-Ottawa scale for observational studies, and the Cochrane Collaboration's risk-of-bias tool for trials. RESULTS:In observational studies, description of enrollment criteria was high but decreased over time. Adequacy of followup was low but improved. Inception cohorts and community-based studies were uncommon. Trials had low risk of bias in blinding and selective outcome reporting but most had unclear risks in sequence generation and allocation concealment. CONCLUSION:Methodological quality was mixed, with limited improvement over time.

SUBMITTER: Tektonidou MG 

PROVIDER: S-EPMC5413417 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Methodological Quality of Studies of Endstage Renal Disease in Lupus Nephritis, 1970 to 2015.

Tektonidou Maria G MG   Ward Michael M MM  

The Journal of rheumatology 20170215 5


<h4>Objective</h4>To examine trends in methodological quality of studies of endstage renal disease risk in lupus nephritis, 1970-2015.<h4>Methods</h4>We assessed quality using the Newcastle-Ottawa scale for observational studies, and the Cochrane Collaboration's risk-of-bias tool for trials.<h4>Results</h4>In observational studies, description of enrollment criteria was high but decreased over time. Adequacy of followup was low but improved. Inception cohorts and community-based studies were unc  ...[more]

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