Ontology highlight
ABSTRACT:
SUBMITTER: Kounatidis I
PROVIDER: S-EPMC5413584 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Kounatidis Ilias I Chtarbanova Stanislava S Cao Yang Y Hayne Margaret M Jayanth Dhruv D Ganetzky Barry B Ligoxygakis Petros P
Cell reports 20170401 4
During aging, innate immunity progresses to a chronically active state. However, what distinguishes those that "age well" from those developing age-related neurological conditions is unclear. We used Drosophila to explore the cost of immunity in the aging brain. We show that mutations in intracellular negative regulators of the IMD/NF-κB pathway predisposed flies to toxic levels of antimicrobial peptides, resulting in early locomotor defects, extensive neurodegeneration, and reduced lifespan. Th ...[more]