Ontology highlight
ABSTRACT:
SUBMITTER: Farine L
PROVIDER: S-EPMC5413845 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Farine Luce L Jelk Jennifer J Choi Jae-Yeon JY Voelker Dennis R DR Nunes Jon J Smith Terry K TK Bütikofer Peter P
Molecular microbiology 20170302 3
Phosphatidylethanolamine (PE) and phosphatidylserine (PS) are ubiquitously expressed and metabolically interconnected glycerophospholipids in eukaryotes and prokaryotes. In Trypanosoma brucei, PE synthesis has been shown to occur mainly via the Kennedy pathway, one of the three routes leading to PE synthesis in eukaryotes, while PS synthesis has not been studied experimentally. We now reveal the importance of T. brucei PS synthase 2 (TbPSS2) and T. brucei PS decarboxylase (TbPSD), two key enzyme ...[more]