Ontology highlight
ABSTRACT:
SUBMITTER: Ngan E
PROVIDER: S-EPMC5413977 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Ngan Elaine E Stoletov Konstantin K Smith Harvey W HW Common Jessica J Muller William J WJ Lewis John D JD Siegel Peter M PM
Nature communications 20170424
We have previously shown that lipoma preferred partner (LPP) mediates TGFβ-induced breast cancer cell migration and invasion. Herein, we demonstrate that diminished LPP expression reduces circulating tumour cell numbers, impairs cancer cell extravasation and diminishes lung metastasis. LPP localizes to invadopodia, along with Tks5/actin, at sites of matrix degradation and at the tips of extravasating breast cancer cells as revealed by intravital imaging of the chick chorioallantoic membrane (CAM ...[more]