Ontology highlight
ABSTRACT:
SUBMITTER: Xie F
PROVIDER: S-EPMC5414047 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Xie Feng F Jin Ke K Shao Li L Fan Yao Y Tu Yifei Y Li Yihao Y Yang Bin B van Dam Hans H Ten Dijke Peter P Weng Honglei H Dooley Steven S Wang Shuai S Jia Junling J Jin Jin J Zhou Fangfang F Zhang Long L
Nature communications 20170426
TGF-β is pro-metastatic for the late-stage breast cancer cells. Despite recent progress, the regulation of TGF-β type II receptor remains uncertain. Here we report that FAF1 destabilizes TβRII on the cell surface by recruiting the VCP/E3 ligase complex, thereby limiting excessive TGF-β response. Importantly, activated AKT directly phosphorylates FAF1 at Ser 582, which disrupts the FAF1-VCP complex and reduces FAF1 at the plasma membrane. The latter results in an increase in TβRII at the cell sur ...[more]