Ontology highlight
ABSTRACT:
SUBMITTER: Lei Y
PROVIDER: S-EPMC5414062 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Lei Yifeng Y Tang Lixue L Xie Yangzhouyun Y Xianyu Yunlei Y Zhang Lingmin L Wang Peng P Hamada Yoh Y Jiang Kai K Zheng Wenfu W Jiang Xingyu X
Nature communications 20170425
Pancreatic cancer is one of the deadliest human cancers, whose progression is highly dependent on the nervous microenvironment. The suppression of gene expression of nerve growth factor (NGF) may have great potential in pancreatic cancer treatment. Here we show that gold nanocluster-assisted delivery of siRNA of NGF (GNC-siRNA) allows efficient NGF gene silencing and pancreatic cancer treatment. The GNC-siRNA complex increases the stability of siRNA in serum, prolongs the circulation lifetime of ...[more]