Ontology highlight
ABSTRACT:
SUBMITTER: Vinckier F
PROVIDER: S-EPMC5414075 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Vinckier F F Gaillard R R Palminteri S S Rigoux L L Salvador A A Fornito A A Adapa R R Krebs M O MO Pessiglione M M Fletcher P C PC
Molecular psychiatry 20150609 7
A state of pathological uncertainty about environmental regularities might represent a key step in the pathway to psychotic illness. Early psychosis can be investigated in healthy volunteers under ketamine, an NMDA receptor antagonist. Here, we explored the effects of ketamine on contingency learning using a placebo-controlled, double-blind, crossover design. During functional magnetic resonance imaging, participants performed an instrumental learning task, in which cue-outcome contingencies wer ...[more]