Ontology highlight
ABSTRACT:
SUBMITTER: Kasahara T
PROVIDER: S-EPMC5414076 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Kasahara T T Takata A A Kato T M TM Kubota-Sakashita M M Sawada T T Kakita A A Mizukami H H Kaneda D D Ozawa K K Kato T T
Molecular psychiatry 20151020 1
Depression is a common debilitating human disease whose etiology has defied decades of research. A critical bottleneck is the difficulty in modeling depressive episodes in animals. Here, we show that a transgenic mouse with chronic forebrain expression of a dominant negative mutant of Polg1, a mitochondrial DNA (mtDNA) polymerase, exhibits lethargic behavioral changes, which are associated with emotional, vegetative and psychomotor disturbances, and response to antidepression drug treatment. The ...[more]