Non-driver mutations in myeloproliferative neoplasm-associated myelofibrosis.
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ABSTRACT:
SUBMITTER: Li B
PROVIDER: S-EPMC5414291 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Non-driver mutations in myeloproliferative neoplasm-associated myelofibrosis.
Li Bing B Gale Robert Peter RP Xu Zefeng Z Qin Tiejun T Song Zhen Z Zhang Peihong P Bai Jie J Zhang Lei L Zhang Yue Y Liu Jinqin J Huang Gang G Xiao Zhijian Z
Journal of hematology & oncology 20170502 1
We studied non-driver mutations in 62 subjects with myeloproliferative neoplasm (MPN)-associated myelofibrosis upon diagnosis, including 45 subjects with primary myelofibrosis (PMF) and 17 with post-polycythemia vera or post-essential thrombocythemia myelofibrosis (post-PV/ET MF). Fifty-eight subjects had ≥1 non-driver mutation upon diagnosis. Mutations in mRNA splicing genes, especially in U2AF1, were significantly more frequent in PMF than in post-PV/ET MF (33 vs. 6%; P = 0.015). There were al ...[more]
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