Hepatitis B serological markers and plasma DNA concentrations.

ABSTRACT:

Objectives

To examine hepatitis B (HBV) serological markers and plasma DNA concentrations in a large group of untreated HBV/HIV-coinfected individuals in two sub-Saharan settings.

Design

Baseline analysis of a randomized controlled trial.

Methods

DART was a large trial of treatment monitoring practices in HIV-infected adults with advanced disease starting antiretroviral therapy at centres in Kampala or Entebbe, Uganda (n = 2317) and Harare, Zimbabwe (n = 999). HBV serological markers [antibody to HBV core antigen, HBV surface antigen (HBsAg), antibody to HBV surface antigen, HBV 'e' antigen (HBeAg), and antibody to hepatitis B 'e' antigen] and plasma HBV DNA viral load were measured retrospectively on stored baseline samples. Logistic regression was used to examine as

SUBMITTER: Price H 

PROVIDER: S-EPMC5414544 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature