Dataset Information

Intratympanic Sustained-Exposure Dexamethasone Thermosensitive Gel for Symptoms of Meniere's Disease: Randomized Phase 2b Safety and Efficacy Trial.

ABSTRACT: To evaluate safety and efficacy of a single intratympanic injection of OTO-104, sustained-exposure dexamethasone, in patients with unilateral Ménière's disease.Randomized, double-blind, placebo-controlled, Phase 2b study over 5 months.Fifty-two academic and community otolaryngology centers.One hundred fifty four patients (77 per group) aged 18 to 85 years inclusive.Single intratympanic injection of OTO-104 (12?mg dexamethasone) or placebo.Efficacy (vertigo) and safety (adverse events, otoscopy, audiometry, tympanometry).Primary endpoint (change from baseline in vertigo rate at Month 3) was not statistically significant (placebo [-43%], OTO-104 [-61%], P?=?0.067). Improvements with OTO-104 were observed in prospectively defined secondary endpoints number of days with definitive vertigo, (Month 2 [P?=?0.035], Month 3 [P?=?0.030]), vertigo severity (Months 2-3, P?=?0.046) and daily vertigo counts (Month 2, P?=?0.042), and in some Short Form-36 (SF-36) subscales (Month 2 bodily pain P?=?0.039, vitality P?=?0.045, social functioning P?=?0.025). No difference in tinnitus loudness or tinnitus handicap inventory (THI-25) was observed. OTO-104 was well tolerated; no negative impact on safety compared with placebo. Persistent tympanic membrane perforation was observed in two OTO-104 treated patients at study end.OTO-104 was well-tolerated, did not significantly affect change from baseline in vertigo rate, but did reduce number definitive vertigo days, vertigo severity, and average daily vertigo count compared with placebo during Month 3. Results provide insight into analyzing for a vertigo treatment effect and support advancing OTO-104 into Phase 3 clinical trials for the treatment of Ménière's disease symptoms.

SUBMITTER: Lambert PR

PROVIDER: S-EPMC5414596 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Intratympanic Sustained-Exposure Dexamethasone Thermosensitive Gel for Symptoms of Ménière's Disease: Randomized Phase 2b Safety and Efficacy Trial.

Lambert Paul R PR Carey John J Mikulec Anthony A AA LeBel Carl C

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 20161201 10

<h4>Objective</h4>To evaluate safety and efficacy of a single intratympanic injection of OTO-104, sustained-exposure dexamethasone, in patients with unilateral Ménière's disease.<h4>Study design</h4>Randomized, double-blind, placebo-controlled, Phase 2b study over 5 months.<h4>Setting</h4>Fifty-two academic and community otolaryngology centers.<h4>Patients</h4>One hundred fifty four patients (77 per group) aged 18 to 85 years inclusive.<h4>Intervention</h4>Single intratympanic injection of OTO-1 ...[more]

PMID: 27749754

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Dataset Information

Intratympanic Sustained-Exposure Dexamethasone Thermosensitive Gel for Symptoms of Meniere's Disease: Randomized Phase 2b Safety and Efficacy Trial.

Publications

Intratympanic Sustained-Exposure Dexamethasone Thermosensitive Gel for Symptoms of Ménière's Disease: Randomized Phase 2b Safety and Efficacy Trial.

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