Ontology highlight
ABSTRACT:
SUBMITTER: Veinalde R
PROVIDER: S-EPMC5414860 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Veinalde Rūta R Grossardt Christian C Hartmann Laura L Bourgeois-Daigneault Marie-Claude MC Bell John C JC Jäger Dirk D von Kalle Christof C Ungerechts Guy G Engeland Christine E CE
Oncoimmunology 20170131 4
Combination of oncolytic virotherapy with immunomodulators is emerging as a promising therapeutic strategy for numerous tumor entities. In this study, we developed measles Schwarz vaccine strain vectors encoding immunomodulators to support different phases in the establishment of antitumor immune responses. Therapeutic efficacy of the novel vectors was evaluated in the immunocompetent MC38cea tumor model. We identified vectors encoding an IL-12 fusion protein (MeVac FmIL-12) and an antibody agai ...[more]