Ontology highlight
ABSTRACT:
SUBMITTER: Xie Q
PROVIDER: S-EPMC5415311 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Molecular therapy. Methods & clinical development 20170308
Atomic structures of adeno-associated virus (AAV)-DJ, alone and in complex with fondaparinux, have been determined by cryoelectron microscopy at 3 Å resolution. The gene therapy vector, AAV-DJ, is a hybrid of natural serotypes that was previously derived by directed evolution, selecting for hepatocyte entry and resistance to neutralization by human serum. The structure of AAV-DJ differs from that of parental serotypes in two regions where neutralizing antibodies bind, so immune escape appears to ...[more]