Multilayer photodynamic therapy for highly effective and safe cancer treatment.

ABSTRACT: Recent efforts to develop tumor-targeted photodynamic therapy (PDT) photosensitizers (PSs) have greatly advanced the potential of PDT in cancer therapy, although complete eradication of tumor cells by PDT alone remains challenging. As a way to improve PDT efficacy, we report a new combinatory PDT therapy technique that specifically targets multilayers of cells. Simply mixing different PDT PSs, even those that target distinct receptors (this may still lead to similar cell-killing pathways), may not achieve ideal therapeutic outcomes. Instead, significantly improved outcomes likely require synergistic therapies that target various cellular pathways. In this study, we target two proteins upregulated in cancers: the cannabinoid CB2 receptor (CB₂R, a G-protein coupled receptor) and t

SUBMITTER: Yang L 

PROVIDER: S-EPMC5415343 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature