Ontology highlight
ABSTRACT:
SUBMITTER: Pirozzi CJ
PROVIDER: S-EPMC5415422 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Pirozzi Christopher J CJ Carpenter Austin B AB Waitkus Matthew S MS Wang Catherine Y CY Zhu Huishan H Hansen Landon J LJ Chen Lee H LH Greer Paula K PK Feng Jie J Wang Yu Y Bock Cheryl B CB Fan Ping P Spasojevic Ivan I McLendon Roger E RE Bigner Darell D DD He Yiping Y Yan Hai H
Molecular cancer research : MCR 20170201 5
<i>IDH1</i> mutations occur in the majority of low-grade gliomas and lead to the production of the oncometabolite, D-2-hydroxyglutarate (D-2HG). To understand the effects of tumor-associated mutant <i>IDH1</i> (IDH1-R132H) on both the neural stem cell (NSC) population and brain tumorigenesis, genetically faithful cell lines and mouse model systems were generated. Here, it is reported that mouse NSCs expressing Idh1-R132H displayed reduced proliferation due to p53-mediated cell-cycle arrest as we ...[more]