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RGC32 induces epithelial-mesenchymal transition by activating the Smad/Sip1 signaling pathway in CRC.


ABSTRACT: Response gene to complement 32 (RGC32) is a transcription factor that regulates the expression of multiple genes involved in cell growth, viability and tissue-specific differentiation. However, the role of RGC32 in tumorigenesis and tumor progression in colorectal cancer (CRC) has not been fully elucidated. Here, we showed that the expression of RGC32 was significantly up-regulated in human CRC tissues versus adjacent normal tissues. RGC32 expression was significantly correlated with invasive and aggressive characteristics of tumor cells, as well as poor survival of CRC patients. We also demonstrated that RGC32 overexpression promoted proliferation, migration and tumorigenic growth of human CRC cells in vitro and in vivo. Functionally, RGC32 facilitated epithelial-mesenchymal transition (EMT) in CRC via the Smad/Sip1 signaling pathway, as shown by decreasing E-cadherin expression and increasing vimentin expression. In conclusion, our findings suggested that overexpression of RGC32 facilitates EMT of CRC cells by activating Smad/Sip1 signaling.

SUBMITTER: Wang XY 

PROVIDER: S-EPMC5415763 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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RGC32 induces epithelial-mesenchymal transition by activating the Smad/Sip1 signaling pathway in CRC.

Wang Xiao-Yan XY   Li Sheng-Nan SN   Zhu Hui-Fang HF   Hu Zhi-Yan ZY   Zhong Yan Y   Gu Chuan-Sha CS   Chen Shi-You SY   Liu Teng-Fei TF   Li Zu-Guo ZG  

Scientific reports 20170504


Response gene to complement 32 (RGC32) is a transcription factor that regulates the expression of multiple genes involved in cell growth, viability and tissue-specific differentiation. However, the role of RGC32 in tumorigenesis and tumor progression in colorectal cancer (CRC) has not been fully elucidated. Here, we showed that the expression of RGC32 was significantly up-regulated in human CRC tissues versus adjacent normal tissues. RGC32 expression was significantly correlated with invasive an  ...[more]

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