Recombinant Salmonella expressing SspH2-EscI fusion protein limits its colonization in mice.
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ABSTRACT:
SUBMITTER: Hu M
PROVIDER: S-EPMC5415771 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
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Recombinant Salmonella expressing SspH2-EscI fusion protein limits its colonization in mice.
Hu Maozhi M Zhao Weixin W Gao Wei W Li Wenhua W Meng Chuang C Yan Qiuxiang Q Wang Yuyang Y Zhou Xiaohui X Geng Shizhong S Pan Zhiming Z Cui Guiyou G Jiao Xinan X
BMC immunology 20170503 1
<h4>Background</h4>Activation of inflammasome contributes to the clearance of intracellular bacteria. C-terminus of E. coli EscI protein can activate NLRC4 (NLR family, CARD domain containing-4) inflammasome in macrophages. The purpose of this study was to determine if activation of NLRC4 inflammasome by EscI can reduce the colonization of Salmonella in mice.<h4>Results</h4>A recombinant S. typhimurium strain expressing fusion protein of the N-terminal SspH2 (a Salmonella type III secretion syst ...[more]
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