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R77Q and Q3R HIV1-VPR mutations in an otherwise asymptomatic 5-year-old child with repeated ear infections.


ABSTRACT: INTRODUCTION:Viral protein R (Vpr) of human immunodeficiency virus type 1 (HIV-1) has been described as being involved in the progression of AIDS, and specific mutations are associated with long-term non-progressor patients. CASE PRESENTATION:We describe the case of a child with repeated ear infections who was otherwise healthy. The patient, a 5-year-old boy, was HIV-1 positive and the viral load at admission was 1?073?899 RNA copies ml-1 and 0?% CD4+ lymphocytes. A detailed study of the vpr gene sequence of the child revealed mutations leading to amino acid substitutions at positions 3 and 77. CONCLUSION:The case reported provides clinical support of previous findings that show that the R77Q and Q3R HIV-1 Vpr variants are associated with patients with delayed disease progression.

SUBMITTER: Soares R 

PROVIDER: S-EPMC5415930 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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R77Q and Q3R HIV1-VPR mutations in an otherwise asymptomatic 5-year-old child with repeated ear infections.

Soares Rui R   Rocha Graça G   Nogueira Célia C   Meliço-Silvestre António A   Gonçalves Teresa T  

JMM case reports 20141201 4


<h4>Introduction</h4>Viral protein R (Vpr) of human immunodeficiency virus type 1 (HIV-1) has been described as being involved in the progression of AIDS, and specific mutations are associated with long-term non-progressor patients.<h4>Case presentation</h4>We describe the case of a child with repeated ear infections who was otherwise healthy. The patient, a 5-year-old boy, was HIV-1 positive and the viral load at admission was 1 073 899 RNA copies ml<sup>-1</sup> and 0 % CD4<sup>+</sup> lymphoc  ...[more]

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