Ontology highlight
ABSTRACT:
SUBMITTER: Ashoor H
PROVIDER: S-EPMC5416852 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Ashoor Haitham H Louis-Brennetot Caroline C Janoueix-Lerosey Isabelle I Bajic Vladimir B VB Boeva Valentina V
Nucleic acids research 20170501 8
Comparing histone modification profiles between cancer and normal states, or across different tumor samples, can provide insights into understanding cancer initiation, progression and response to therapy. ChIP-seq histone modification data of cancer samples are distorted by copy number variation innate to any cancer cell. We present HMCan-diff, the first method designed to analyze ChIP-seq data to detect changes in histone modifications between two cancer samples of different genetic backgrounds ...[more]