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Transmission Incompetence of Culex quinquefasciatus and Culex pipiens pipiens from North America for Zika Virus.


ABSTRACT: AbstractIn late 2014, Zika virus (ZIKV; Flaviviridae, Flavivirus) emerged as a significant arboviral disease threat in the Western hemisphere. Aedes aegypti and Aedes albopictus have been considered the principal vectors of ZIKV in the New World due to viral isolation frequency and vector competence assessments. Limited reports of Culex transmission potential have highlighted the need for additional vector competence assessments of North American Culex species. Accordingly, North American Culex pipiens and Culex quinquefasciatus were orally exposed and intrathoracically inoculated with the African prototype ZIKV strain and currently circulating Asian lineage ZIKV strains to assess infection, dissemination, and transmission potential. Results indicated that these two North American Culex mosquito species were highly refractory to oral infection with no dissemination or transmission observed with any ZIKV strains assessed. Furthermore, both Culex mosquito species intrathoracically inoculated with either Asian or African lineage ZIKVs failed to expectorate virus in saliva. These in vivo results were further supported by the observation that multiple mosquito cell lines of Culex species origin demonstrated significant growth restriction of ZIKV strains compared with Aedes-derived cell lines. In summation, no evidence for the potential of Cx. pipiens or Cx. quinquefasciatus to serve as a competent vector for ZIKV transmission in North America was observed.

SUBMITTER: Kenney JL 

PROVIDER: S-EPMC5417222 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Transmission Incompetence of <i>Culex quinquefasciatus</i> and <i>Culex pipiens pipiens</i> from North America for Zika Virus.

Kenney Joan L JL   Romo Hannah H   Duggal Nisha K NK   Tzeng Wen-Pin WP   Burkhalter Kristen L KL   Brault Aaron C AC   Savage Harry M HM  

The American journal of tropical medicine and hygiene 20170501 5


AbstractIn late 2014, Zika virus (ZIKV; <i>Flaviviridae</i>, <i>Flavivirus</i>) emerged as a significant arboviral disease threat in the Western hemisphere. <i>Aedes aegypti</i> and <i>Aedes albopictus</i> have been considered the principal vectors of ZIKV in the New World due to viral isolation frequency and vector competence assessments. Limited reports of <i>Culex</i> transmission potential have highlighted the need for additional vector competence assessments of North American <i>Culex</i> s  ...[more]

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