Quantitative Age-specific Variability of Plasma Proteins in Healthy Neonates, Children and Adults.

ABSTRACT: Human blood plasma is a complex biological fluid containing soluble proteins, sugars, hormones, electrolytes, and dissolved gasses. As plasma interacts with a wide array of bodily systems, changes in protein expression, or the presence or absence of specific proteins are regularly used in the clinic as a molecular biomarker tool. A large body of literature exists detailing proteomic changes in pathologic contexts, however little research has been conducted on the quantitation of the plasma proteome in age-specific, healthy subjects, especially in pediatrics. In this study, we utilized SWATH-MS to identify and quantify proteins in the blood plasma of healthy neonates, infants under 1 year of age, children between 1-5 years, and adults. We identified more than 100 proteins that showed signif

SUBMITTER: Bjelosevic S 

PROVIDER: S-EPMC5417830 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature