Ontology highlight
ABSTRACT:
SUBMITTER: Palomino R
PROVIDER: S-EPMC5418061 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Palomino Rafael R Lee Hsiau-Wei HW Millhauser Glenn L GL
The Journal of biological chemistry 20170306 18
Syndecans potently modulate agouti-related peptide (AgRP) signaling in the central melanocortin system. Through heparan sulfate moieties, syndecans are thought to anchor AgRP near its receptor, enhancing its orexigenic effects. Original work proposed that the N-terminal domain of AgRP facilitates this interaction. However, this is not compatible with evidence that this domain is posttranslationally cleaved. Addressing this long-standing incongruity, we used calorimetry and magnetic resonance to ...[more]