Differences in the frequency of macrophage and T cell markers between focal and crescentic classes of anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis.

ABSTRACT:

Background

Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN) can be classified into; focal, crescentic, mixed and sclerotic classes. Macrophages and T lymphocytes are key players in mediating renal injury. The frequency of macrophage and T lymphocytes in different histological classes is unclear.

Objectives

We examined the frequency of macrophage and T lymphocyte markers in AAGN and assessed their correlation with renal function at presentation.

Patients and methods

Renal biopsies from 38 patients were included in immunohistochemistry analysis of macrophages (CD68, sialoadhesin [Sn] and mannose receptor [MR]) and T cells (CD4 and CD8) markers. The frequency of these markers in glomerular, periglomerular and interstitial compartments were

SUBMITTER: Kidder D 

PROVIDER: S-EPMC5418077 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature