Dataset Information

Vitamin D₃ supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR^-/- and LDLR^+/+ mice.

ABSTRACT:

Introduction

Fatty liver disease is prevalent in populations with high caloric intake. Nutritherapeutic approaches are being considered, such as supplementary Vitamin D₃ , to improve aspects of metabolic syndrome, namely fatty liver disease, hyperlipidemia, and insulin resistance associated with obesity.

Methods

We analyzed female LDLR^-/- and LDLR^+/+ mice on a 10-week diabetogenic diet for markers of fatty liver disease, metabolic strain, and inflammation.

Results

The groups on a high fat high sugar diet with supplementary Vitamin D₃ , in comparison with the groups on a high fat high sugar diet alone, showed improved transaminase levels, significantly less hypertriglyceridemia and hyperinsulinemia, and histologically, there was less pericentral hepatic steatosis. Levels of non-esterified fatty acids and lipid peroxidation products were significantly lower in the group supplemented with additional Vitamin D₃ , as were systemic markers of inflammation (serum endotoxin and IL-6). M2 macrophage phenotype predominated in the group supplemented with additional Vitamin D₃ . Beneficial changes were observed as early as five weeks' supplementation with Vitamin D₃ and extended to restoration of high fat high sugar diet induced decrease of bone mineral density.

Conclusion

In summary, Vitamin D₃ was a significantly beneficial dietary additive to blunt a prediabetic phenotype in diet-induced obesity of female LDLR^-/- and LDLR^+/+ mice.

SUBMITTER: Kheder R

PROVIDER: S-EPMC5418139 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Publications

Vitamin D<sub>3</sub> supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR<sup>-/-</sup> and LDLR<sup>+/+</sup> mice.

Kheder Ramiar R Hobkirk James J Saeed Zeayd Z Janus Justyna J Carroll Sean S Browning Michael J MJ Stover Cordula C

Immunity, inflammation and disease 20170313 2

<h4>Introduction</h4>Fatty liver disease is prevalent in populations with high caloric intake. Nutritherapeutic approaches are being considered, such as supplementary Vitamin D<sub>3</sub> , to improve aspects of metabolic syndrome, namely fatty liver disease, hyperlipidemia, and insulin resistance associated with obesity.<h4>Methods</h4>We analyzed female LDLR<sup>-/-</sup> and LDLR<sup>+/+</sup> mice on a 10-week diabetogenic diet for markers of fatty liver disease, metabolic strain, and infla ...[more]

PMID: 28474500

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Dataset Information

Vitamin D₃ supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR^-/- and LDLR^+/+ mice.

Introduction

Methods

Results

Conclusion

Publications

Vitamin D<sub>3</sub> supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR<sup>-/-</sup> and LDLR<sup>+/+</sup> mice.

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Vitamin D3 supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR-/- and LDLR+/+ mice.

Introduction

Methods

Results

Conclusion

Publications

Vitamin D<sub>3</sub> supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR<sup>-/-</sup> and LDLR<sup>+/+</sup> mice.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Vitamin D₃ supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR^-/- and LDLR^+/+ mice.