Ontology highlight
ABSTRACT:
SUBMITTER: Mullers E
PROVIDER: S-EPMC5418196 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Müllers Erik E Silva Cascales Helena H Burdova Kamila K Macurek Libor L Lindqvist Arne A
Aging cell 20170326 3
In response to DNA damage, a cell can be forced to permanently exit the cell cycle and become senescent. Senescence provides an early barrier against tumor development by preventing proliferation of cells with damaged DNA. By studying single cells, we show that Cdk activity persists after DNA damage until terminal cell cycle exit. This low level of Cdk activity not only allows cell cycle progression, but also promotes cell cycle exit at a decision point in G2 phase. We find that residual Cdk1/2 ...[more]