Ontology highlight
ABSTRACT:
SUBMITTER: Gorelik A
PROVIDER: S-EPMC5418580 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Gorelik Anna A Sapir Tamar T Haffner-Krausz Rebecca R Olender Tsviya T Woodruff Trent M TM Reiner Orly O
Nature communications 20170502
In recent years the notion that malfunctioning of the immune system may result in developmental brain diseases has emerged. However, the role of immune molecules in the developing brain has not been well explored. The complement pathway converges to cleave C3. Here we show that key proteins in the lectin arm of this pathway, MASP1, MASP2 and C3, are expressed in the developing cortex and that neuronal migration is impaired in knockout and knockdown mice. Molecular mimics of C3 cleavage products ...[more]