Ontology highlight
ABSTRACT:
SUBMITTER: Abolins S
PROVIDER: S-EPMC5418598 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Abolins Stephen S King Elizabeth C EC Lazarou Luke L Weldon Laura L Hughes Louise L Drescher Paul P Raynes John G JG Hafalla Julius C R JCR Viney Mark E ME Riley Eleanor M EM
Nature communications 20170503
The laboratory mouse is the workhorse of immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice, finding that wild mouse cellular immune systems are, comparatively, in a highly activated (primed) state. Associations between immune parameters and infection ...[more]