Ontology highlight
ABSTRACT:
SUBMITTER: Prendergast JM
PROVIDER: S-EPMC5419082 | biostudies-literature | 2017 May/Jun
REPOSITORIES: biostudies-literature
Prendergast Jillian M JM Galvao da Silva Ana Paula AP Eavarone David A DA Ghaderi Darius D Zhang Mai M Brady Dane D Wicks Joan J DeSander Julie J Behrens Jeff J Rueda Bo R BR
mAbs 20170222 4
Targeted therapeutics that can differentiate between normal and malignant tumor cells represent the ideal standard for the development of a successful anti-cancer strategy. The Sialyl-Thomsen-nouveau antigen (STn or Sialyl-Tn, also known as CD175s) is rarely seen in normal adult tissues, but it is abundantly expressed in many types of human epithelial cancers. We have identified novel antibodies that specifically target with high affinity the STn glycan independent of its carrier protein, afford ...[more]