A Report of Adult Human Adenovirus Infections in a Tertiary Hospital.
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ABSTRACT:
SUBMITTER: Kalimuddin S
PROVIDER: S-EPMC5419200 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
A Report of Adult Human Adenovirus Infections in a Tertiary Hospital.
Kalimuddin Shirin S Chan Yvonne F Z YFZ Wu Ian Q IQ Tan Qiao Li QL Murthee Kavitha G KG Tan Ban Hock BH Oon Lynette L E LLE Yang Yong Y Lin Raymond T P RTP Joseph Udayan U Sessions October M OM Smith Gavin J D GJD Ooi Eng Eong EE Low Jenny G H JGH
Open forum infectious diseases 20170325 2
We describe a review of human adenovirus (HAdV) infections occurring among adults in a tertiary hospital in Singapore from February to May 2013. A similar increase in cases was observed among children and military personnel during the same time period. The majority of isolates were identified as HAdV-7, likely an emerging pathogen in Asia. ...[more]
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Project description:Here we summarize an April 2016, 7-patient cluster of human adenovirus (HAdV) infections in a cardiothoracic surgery intensive care unit. We show that the patients were infected with a single HAdV21b type. Rapid HAdV typing diagnostics and effective antiviral interventions are needed for immunocompromised patients suffering from HAdV infections.
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Project description:SettingTribhuvan University Teaching Tertiary Care Hospital, Kathmandu, Nepal, May-October 2019.Objective1) To describe the bacteriological profile, 2) to identify the antimicrobial resistance (AMR) pattern, and 3) to find the demographic characteristics associated with the presence of bacterial growth and multidrug resistance (MDR) in adult urine samples undergoing culture and drug susceptibility testing.DesignThis was a hospital-based, cross-sectional study using routine laboratory records.ResultsAmong 11,776 urine samples, 16% (1,865/11,776) were culture-positive, predominantly caused by Escherichia coli (1,159/1,865; 62%). We found a high prevalence of resistance to at least one antibiotic (1,573/1,865; 84%) and MDR (1,000/1,865; 54%). Resistance to commonly used antibiotics for urinary tract infections (UTIs) such as ceftazidime, levofloxacin, cefepime and ampicillin was high. Patients aged ⩾60 years (adjusted prevalence ratio [aPR] 1.6, 95% CI 1.4-1.7) were more likely to have culture positivity. Patients with age ⩾45 years (45-59 years: aPR 1.5, 95% CI 1.3-1.7; ⩾60 years: aPR 1.4, 95% CI 1.2-1.6), male sex (aPR 1.3, 95% CI 1.2-1.5) and from inpatient settings (aPR 1.4, 95% CI 1.2-1.7) had significantly higher prevalence of MDR.ConclusionUrine samples from a tertiary hospital showed high prevalence of E. coli and MDR to routinely used antibiotics, especially among inpatients. Regular surveillance and application of updated antibiograms are crucial to monitor the AMR situation in Nepal.
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