Ontology highlight
ABSTRACT:
SUBMITTER: Shugay M
PROVIDER: S-EPMC5419444 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Shugay Mikhail M Zaretsky Andrew R AR Shagin Dmitriy A DA Shagina Irina A IA Volchenkov Ivan A IA Shelenkov Andrew A AA Lebedin Mikhail Y MY Bagaev Dmitriy V DV Lukyanov Sergey S Chudakov Dmitriy M DM
PLoS computational biology 20170505 5
Unique molecular identifiers (UMIs) show outstanding performance in targeted high-throughput resequencing, being the most promising approach for the accurate identification of rare variants in complex DNA samples. This approach has application in multiple areas, including cancer diagnostics, thus demanding dedicated software and algorithms. Here we introduce MAGERI, a computational pipeline that efficiently handles all caveats of UMI-based analysis to obtain high-fidelity mutation profiles and c ...[more]