Ontology highlight
ABSTRACT:
SUBMITTER: Chao G
PROVIDER: S-EPMC5419568 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Chao Gao G Tian Xiaoning X Zhang Wentao W Ou Xuehai X Cong Fei F Song Tao T
PloS one 20170505 5
The activity of Schwann cells (SWCs) is very important in trauma-induced nerve repair, and tumour necrosis factor-α (TNF-α) produced during tissue injury inhibits the viability of SWCs, which delays the repair of peripheral nerves. Loganin is an iridoid glycoside that has been shown to alleviate a variety of cytotoxic effects. In the current study, we evaluated the potential efficacy and the mechanism of action of loganin in TNF-α-induced cytotoxicity in SW10 cells. The experimental results indi ...[more]