Ontology highlight
ABSTRACT:
SUBMITTER: Nounamo B
PROVIDER: S-EPMC5419587 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Nounamo Bernice B Li Yibo Y O'Byrne Peter P Kearney Aoife M AM Khan Amir A Liu Jia J
Virology 20170131
In humans, deleterious mutations in the sterile α motif domain protein 9 (SAMD9) gene are associated with cancer, inflammation, weakening of the immune response, and developmental arrest. However, the biological function of SAMD9 and its sequence-structure relationships remain to be characterized. Previously, we found that an essential host range factor, M062 protein from myxoma virus (MYXV), antagonized the function of human SAMD9. In this study, we examine the interaction between M062 and huma ...[more]