Ontology highlight
ABSTRACT:
SUBMITTER: Honeycutt JB
PROVIDER: S-EPMC5419854 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Honeycutt Jenna B JB Thayer William O WO Baker Caroline E CE Ribeiro Ruy M RM Lada Steven M SM Cao Youfang Y Cleary Rachel A RA Hudgens Michael G MG Richman Douglas D DD Garcia J Victor JV
Nature medicine 20170417 5
Despite years of fully suppressive antiretroviral therapy (ART), HIV persists in its hosts and is never eradicated. One major barrier to eradication is that the virus infects multiple cell types that may individually contribute to HIV persistence. Tissue macrophages are critical contributors to HIV pathogenesis; however, their specific role in HIV persistence during long-term suppressive ART has not been established. Using humanized myeloid-only mice (MoM), we demonstrate that HIV infection of t ...[more]