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ABSTRACT:
SUBMITTER: Hormozdiari F
PROVIDER: S-EPMC5420356 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Hormozdiari Farhad F Zhu Anthony A Kichaev Gleb G Ju Chelsea J-T CJ Segrè Ayellet V AV Joo Jong Wha J JWJ Won Hyejung H Sankararaman Sriram S Pasaniuc Bogdan B Shifman Sagiv S Eskin Eleazar E
American journal of human genetics 20170501 5
Recent successes in genome-wide association studies (GWASs) make it possible to address important questions about the genetic architecture of complex traits, such as allele frequency and effect size. One lesser-known aspect of complex traits is the extent of allelic heterogeneity (AH) arising from multiple causal variants at a locus. We developed a computational method to infer the probability of AH and applied it to three GWASs and four expression quantitative trait loci (eQTL) datasets. We ide ...[more]