Ontology highlight
ABSTRACT:
SUBMITTER: Carnemolla A
PROVIDER: S-EPMC5420564 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Carnemolla Alisia A Michelazzi Silvia S Agostoni Elena E
Frontiers in cellular neuroscience 20170508
Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder characterized by a polyglutamine expansion within the N-terminal region of huntingtin protein (HTT). Cellular mechanisms promoting mutant huntingtin (mHTT) clearance are of great interest in HD pathology as they can lower the level of the mutant protein and its toxic aggregated species, thus affecting disease onset and progression. We have previously shown that the prolyl-isomerase PIN1 represents a promising negative ...[more]