Ontology highlight
ABSTRACT:
SUBMITTER: Johannesen L
PROVIDER: S-EPMC5421403 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Johannesen L L Vicente J J Mason J W JW Erato C C Sanabria C C Waite-Labott K K Hong M M Lin J J Guo P P Mutlib A A Wang J J Crumb W J WJ Blinova K K Chan D D Stohlman J J Florian J J Ugander M M Stockbridge N N Strauss D G DG
Clinical pharmacology and therapeutics 20151128 2
Drug-induced long QT syndrome has resulted in many drugs being withdrawn from the market. At the same time, the current regulatory paradigm for screening new drugs causing long QT syndrome is preventing drugs from reaching the market, sometimes inappropriately. In this study, we report the results of a first-of-a-kind clinical trial studying late sodium (mexiletine and lidocaine) and calcium (diltiazem) current blocking drugs to counteract the effects of hERG potassium channel blocking drugs (do ...[more]