Hypoxia Inducible Factor 1: A Urinary Biomarker of Kidney Disease.
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ABSTRACT:
SUBMITTER: Movafagh S
PROVIDER: S-EPMC5421733 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
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Hypoxia Inducible Factor 1: A Urinary Biomarker of Kidney Disease.
Movafagh S S Raj D D Sanaei-Ardekani M M Bhatia D D Vo K K Mahmoudieh M M Rahman R R Kim E H EH Harralson A F AF
Clinical and translational science 20170209 3
Identifying noninvasive biomarkers of kidney disease is valuable for diagnostic and therapeutic purposes. Hypoxia inducible factor 1 (HIF-1) expression is known to be elevated in the kidneys in several renal disease pathologies. We hypothesized that the urinary HIF-1a mRNA level may be a suitable biomarker for expression of this protein in chronic kidney disease (CKD). We compared HIF-1a mRNA levels from urine pellets of CKD and healthy subjects. To ensure that urinary HIF-1a mRNA is of kidney o ...[more]
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