Dataset Information

Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population.

ABSTRACT: Genome-wide association studies and meta-analyses implicated that increased risk of developing Alzheimer's diseases (AD) has been associated with the ABCA7, APOE, BIN1, CASS4, CD2AP, CD33, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB1, HLA-DRB4, INPP5D, MEF2C, MS4A4A, MS4A4E, MS4A6E, NME8, PICALM, PLD3, PTK2B, RIN3, SLC24A4, SORL1, and ZCWPW1 genes. In this study, we assessed whether single nucleotide polymorphisms (SNPs) within these 27 AD-associatedgenes are linked with cognitive aging independently and/or through complex interactions in an older Taiwanese population. We also analyzed the interactions between lifestyle and these genes in influencing cognitive aging. A total of 634 Taiwanese subjects aged over 60 years from the Taiwan Biobank were analyzed. Mini-Mental State Examination (MMSE) scores were performed for all subjects to evaluate cognitive functions. Out of the 588 SNPs tested in this study, only the association between CASS4-rs911159 and cognitive aging persisted significantly (P = 2.2 x 10-5) after Bonferroni correction. Our data also showed a nominal association of cognitive aging with the SNPs in six more key AD-associated genes, including EPHA1-rs10952552, FERMT2-rs4901317, MEF2C-rs9293506, PLD3-rs11672825, RIN3-rs1885747, and SLC24A4-rs67063100 (P = 0.0018~0.0097). Additionally, we found the interactions among CASS4-rs911159, EPHA-rs10952552, FERMT2-rs4901317, MEF2C-rs9293506, or SLC24A4-rs67063100 on cognitive aging (P = 0.004~0.035). Moreover, our analysis suggested the interactions of SLC24A4-rs67063100 or MEF2C-rs9293506 with lifestyle such as alcohol consumption, smoking status, physical activity, or social support on cognitive aging (P = 0.008~0.041). Our study indicates that the AD-associated genes may contribute to the risk of cognitive aging independently as well as through gene-gene and gene-lifestyle interactions.

SUBMITTER: Lin E

PROVIDER: S-EPMC5421828 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population.

Lin Eugene E Tsai Shih-Jen SJ Kuo Po-Hsiu PH Liu Yu-Li YL Yang Albert C AC Kao Chung-Feng CF

Oncotarget 20170401 15

Genome-wide association studies and meta-analyses implicated that increased risk of developing Alzheimer's diseases (AD) has been associated with the ABCA7, APOE, BIN1, CASS4, CD2AP, CD33, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB1, HLA-DRB4, INPP5D, MEF2C, MS4A4A, MS4A4E, MS4A6E, NME8, PICALM, PLD3, PTK2B, RIN3, SLC24A4, SORL1, and ZCWPW1 genes. In this study, we assessed whether single nucleotide polymorphisms (SNPs) within these 27 AD-associatedgenes are linked with cognitive aging indepe ...[more]

PMID: 28199971

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Project description:Population aging is escalating in numerous countries worldwide; among them is Taiwan, which will soon become an aged society. Thus, aging successfully is an increasing concern. One of the factors for achieving successful aging (SA) is maintaining high physical function. The purpose of this study was to determine the physical fitness factors associated with SA in Taiwanese older adults (OAs), because these factors are intervenable. Community-dwelling OAs aged more than 65 years and residing in Northern Taiwan were recruited in this study. They received a comprehensive geriatric assessment, which includes sociodemographic data, health conditions and behaviors, activities of daily living (ADL) and instrumental ADL (IADL) function, cognitive and depressive status, and quality of life. Physical fitness tests included the grip strength (GS), 30-second sit-to-stand (30s STS), timed up-and-go (TUG), functional reach (FR), one-leg standing, chair sit-and-reach, and reaction time (drop ruler) tests as well as the 6-minute walk test (6MWT). SA status was defined as follows: complete independence in performing ADL and IADL, satisfactory cognitive status (Mini-Mental State Examination ≥ 24), no depression (Geriatric Depression Scale < 5), and favorable social function (SF subscale ≥ 80 in SF-36). Adjusted multiple logistic regression analyses were performed. Among the total recruited OAs (n = 378), 100 (26.5%) met the aforementioned SA criteria. After adjustment for sociodemographic characteristics and health condition and behaviors, some physical fitness tests, namely GS, 30s STS, 6MWT, TUG, and FR tests, were significantly associated with SA individually, but not in the multivariate model. Among the physical fitness variables tested, cardiopulmonary endurance, mobility, muscle strength, and balance were significantly associated with SA in Taiwanese OAs. Early detection of deterioration in the identified functions and corresponding intervention is essential to ensuring SA.

Project description:Background: Epidemiological studies of the effect of physical activity on cognition demonstrated an inverse relationship between physical activity and cognitive decline. However, such health behaviors are hardly invariable over time. The relative homogeneity of the adult lifestyle of nuns/monks as well as master athletes reduces the likelihood of confounding due to differences in their participation in regular life-long physical activities. The purpose of this study was to determine if there were differences in cognitive functions between nuns/monks, master athletes and sedentary, but otherwise healthy older adults. Additionally, we examined associations between demographic variables (education, sex, age), BMI, physical activity, exercise, and fitness and cognitive performance. Methods: We recruited three groups of healthy participants without cognitive deficits: (1) Nuns/Monks (n = 20; age 77.5 ± 5.56; 5 M, 15 W), (2) Master Athletes (n = 20; age 76.5 ± 5.33; 12 M, 8 W), and (3) Sedentary (n = 20; 76.4 ± 5.96, 6 M, 14 W). Cognitive performance (working memory, inhibition) was measured with a n-back task and a flanker task, participation in physical activities with the "German-PAQ-50+," and physical fitness with the 30s chair stand and arm curl test. Results: As predicted, ANOVA comparing groups revealed the three groups differed in cognition, physical activity, and physical fitness with inactive older adults performing lower on all tests than the other two groups. Hierarchical regression analyses showed a positive influence of lifestyle stability on accuracy and reaction time for working memory and inhibitory performance. The highest correlation coefficients for fitness and cognitive performance emerged for the group of nuns and monks. Conclusion: Life-long stability of an active lifestyle may confer benefits to some aspects of working memory, attention, and inhibitory control. Longitudinal studies are recommended to further examine the causal relationship of lifestyle stability and cognitive function in such specific cohorts.

Dataset Information

Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population.

Publications

Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population.

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